Development of Burkholderia mallei and pseudomallei vaccines
نویسندگان
چکیده
منابع مشابه
Development of Burkholderia mallei and pseudomallei vaccines
Burkholderia mallei and Burkholderia pseudomallei are Gram-negative bacteria that cause glanders and melioidosis, respectively. Inhalational infection with either organism can result in severe and rapidly fatal pneumonia. Inoculation by the oral and cutaneous routes can also produce infection. Chronic infection may develop after recovery from acute infection with both agents, and control of inf...
متن کاملDevelopment of Vaccines Against Burkholderia Pseudomallei
Burkholderia pseudomallei is a Gram-negative bacterium which is the causative agent of melioidosis, a disease which carries a high mortality and morbidity rate in endemic areas of South East Asia and Northern Australia. At present there is no available human vaccine that protects against B. pseudomallei, and with the current limitations of antibiotic treatment, the development of new preventati...
متن کاملBurkholderia pseudomallei and Burkholderia mallei: Melioidosis and Glanders
The genus Burkholderia is currently composed of many species, but only three are notable pathogens for humans or animals: the former cepacia complex (described in Chapter 220) pseudomallei (the agent of melioidosis), and mallei (the agent of equine glanders). All three are aerobic, nonsporulating, straight or slightly curved gram-negative bacilli that were formerly placed in the genus Pseudomonas.
متن کاملAntimicrobial Drug–Selection Markers for Burkholderia pseudomallei and B. mallei
Genetic research into the select agents Burkholderia pseudomallei and B. mallei is currently hampered by a paucity of approved antimicrobial drug-selection markers. The strict regulations imposed on researchers in the United States but not in other parts of the world lead to discrepancies in practice, hinder distribution of genetically modified strains, and impede progress in the field. Deliber...
متن کاملAutotransporters and Their Role in the Virulence of Burkholderia pseudomallei and Burkholderia mallei
Burkholderia pseudomallei and Burkholderia mallei are closely related Gram-negative bacteria responsible for the infectious diseases melioidosis and glanders, respectively. Autotransporters (ATs) comprise a large and diverse family of secreted and outer membrane proteins that includes virulence-associated invasins, adhesins, proteases, and actin-nucleating factors. The B. pseudomallei K96243 ge...
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ژورنال
عنوان ژورنال: Frontiers in Cellular and Infection Microbiology
سال: 2013
ISSN: 2235-2988
DOI: 10.3389/fcimb.2013.00010